Table 2.
Lists of differentially expressed genes based on RNAseq.
| Gene symbol | Description | Fold change (log2) | Adjusted p value |
|---|---|---|---|
| (a) List of top 10 genes upregulated in SS (n = 8) than non-SS (n = 8) | |||
| LTF | Lactotransferrin | 0.980 | 0.099 |
| REC8 | REC8 meiotic recombination protein | 0.947 | 0.099 |
| HCP5 | HLA complex P5 (non-protein coding) | 0.935 | 0.099 |
| SMPX | Small muscle protein, X-linked | 0.908 | NA |
| IL15 | Interleukin 15 | 0.882 | NA |
| CA13 | Carbonic anhydrase XIII | 0.816 | 0.099 |
| SNORD116-6 | Small nucleolar RNA, C/D box 116-6 | 0.806 | 0.272 |
| APOL1 | Apolipoprotein L, 1 | 0.802 | 0.197 |
| HLA-F | Major histocompatibility complex, class I, F | 0.793 | 0.256 |
| CD8A | CD8a molecule | 0.792 | NA |
| (b) List of top 10 genes downregulated in SS (n = 8) than non-SS (n = 8) | |||
| CA8 | Carbonic anhydrase VIII | − 0.762 | 0.275 |
| CABS1 | Calcium-binding protein, spermatid-specific 1 | − 0.757 | 0.275 |
| FDPSP5 | Farnesyl diphosphate synthase pseudogene 5 | − 0.730 | NA |
| SCD | Stearoyl-CoA desaturase (delta-9-desaturase) | − 0.729 | 0.275 |
| SCDP1 | Stearoyl-CoA desaturase (delta-9-desaturase) pseudogene 1 | − 0.725 | NA |
| LINC01207 | Long intergenic non-protein coding RNA 1207 | − 0.718 | 0.326 |
| RSL24D1P1 | Ribosomal L24 domain containing 1 pseudogene 1 | − 0.716 | NA |
| VSIG10L | V-set and immunoglobulin domain containing 10 like | − 0.669 | 0.348 |
| SEMA3D | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | − 0.668 | NA |
| UNC5A | Unc-5 homolog A | − 0.659 | 0.408 |
| (c) List of top 10 genes after RNAseq subclustering that are upregulated in Group B (n = 3) than Group A (n = 3) | |||
| MMP7 | Matrix metallopeptidase 7 | 2.522 | 7.36 × 10–8 |
| LINC00639 | Long intergenic non-protein coding RNA 639 | 2.297 | 2.96 × 10–6 |
| KCNB1 | Potassium channel, voltage gated Shab related subfamily B, member 1 | 2.274 | 3.30 × 10–7 |
| LINC00284 | Long intergenic non-protein coding RNA 284 | 2.273 | 3.61 × 10–6 |
| CLU | Clusterin | 2.223 | 2.73 × 10–9 |
| RARRES1 | Retinoic acid receptor responder (tazarotene induced) 1 | 2.125 | 2.70 × 10–6 |
| C19orf68 | Chromosome 19 open reading frame 68 | 2.119 | 4.17 × 10–6 |
| SH3D21 | SH3 domain containing 21 | 2.062 | 5.81 × 10–6 |
| BMP3 | Bone morphogenetic protein 3 | 2.057 | 6.22 × 10–6 |
| SLC38A3 | Solute carrier family 38, member 3 | 2.022 | NA |
| (d) List of top 10 genes after RNAseq subclustering that are downregulated in Group B (n = 3) than Group A (n = 3) | |||
| CALML5 | Calmodulin-like 5 | − 2.407 | 4.46 × 10–17 |
| VSIG10L | V-set and immunoglobulin domain containing 10 like | − 2.375 | 9.37 × 10–15 |
| HPSE | Heparanase | − 2.152 | 1.52 × 10–6 |
| CABS1 | Calcium-binding protein, spermatid-specific 1 | − 2.081 | 7.43 × 10–6 |
| MUC7 | Mucin 7, secreted | − 2.008 | 7.88 × 10–8 |
| FGF12 | Fibroblast growth factor 12 | − 1.946 | 1.28 × 10–7 |
| TESC | Tescalcin | − 1.911 | 1.41 × 10–6 |
| DNASE2B | Deoxyribonuclease II beta | − 1.898 | 0.000155 |
| SCD | Stearoyl-CoA desaturase (delta-9-desaturase) | − 1.863 | 3.99 × 10–6 |
| FADS2 | Fatty acid desaturase 2 | − 1.853 | 1.54 × 10–5 |