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. 2021 May 27;11:11211. doi: 10.1038/s41598-021-90613-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prediction of the homicorcin gene cluster and comparison with other class I lantibiotics. (A) Inhibitory activity of Staphylococcus hominis strain MBL_AB63 (activity overlay assay against Staphylococcus aureus SG511). (B) Biosynthetic gene cluster of different class I lantibiotics. Homicorcin gene cluster was predicted using BAGEL 4.0 (homO: 3-oxoacyl-[acyl-carrier-protein] reductase gene; homI: immunity gene; homA: homicorcin gene; homP: protease gene for leader peptide cleavage; homBC: genes for post translational modification enzyme). (C) Comparisons between the peptide sequences of homicorcin and other class I lantibiotics (residues not similar to Epicidin 280 are shown in red).