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. 2021 May 27;11:11239. doi: 10.1038/s41598-021-90662-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment effect on tumor volumes, cell proliferation and overall survival. (a) Representative T2w-MRI and [¹⁸F]-FLT images for the three different groups of rats before and after treatments. From the top to the bottom: T2w-MRI before treatment (D21); T2w-MRI one day after treatments (D24); [¹⁸F]-FLT images at D24 and lastly, T2w-MRI at D28 and D42. Quantitative analyzes of SUV-[¹⁸F]-FLT one day after treatments in (b) striatal metastases and (c) cortical metastases. Mean ± SD, n = 7 for Control and RT groups and n = 6 for HIGRT group, *p < 0.05 and **p < 0.01 versus Control group and ^#p < 0.05 versus RT group. Quantitative analyzes of tumor volume before and after treatment in (d) striatal metastases and (e) cortical metastases (TMT: treatments). Mean ± SD, n = 7 for Control and RT groups and n = 6 for HIGRT group, ***p < 0.001 versus Control group and ^###p < 0.001 versus RT group. (f) Kaplan–Meier curves of survival, n = 6 for Control, n = 7 for RT and n = 5 for HIGRT groups. **p < 0.01 and ***p < 0.001 versus Control group and ^##p < 0.01 versus RT group.