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. 2021 May 27;11:11168. doi: 10.1038/s41598-021-90605-9

Figure 1.

Figure 1

Representative VDR, COX-2, and miR-26b-5p expression in placenta and trophoblasts from normotensive pregnant women and women complicated with preeclampsia (PE). (A) VDR expression and COX-2 expression in placental tissues from 12 pregnant women (6 from normotensive and 6 from PE). Strong VDR staining was seen in the placentas from normotensive pregnant women compared to those from women with PE. In contrast, intensive COX-2 expression was detected in placentas from PE specimens. Bar = 100 micron. (B) Representative blots of VDR protein expression in placental trophoblast cells (TCs) isolated from 10 pregnant women (5 from normotensive and 5 from PE). The scatter plots show relative VDR expression after normalized by β-actin expression in each sample. *P < 0.05: PE-TC vs Normal-TC. (C) Representative miR-26b-5p expression in placental tissues from 10 pregnant women (5 from normotensive and 5 from PE). The scatter plots show the relative miR-26b-5p expression after normalized by U6 expression in each sample. *P < 0.05: PE vs Normal. These results indicate that reduced VDR expression is associated with decreased miR-26b-5p expression and increased COX-2 expression in the placenta of women with PE.