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. 2021 May 27;11:11168. doi: 10.1038/s41598-021-90605-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-effects of vitamin D and CoCl₂ on COX-2 expression in placental trophoblasts. (A) Protein expression for COX-2 in HTR-8/SVneo cells treated with different concentrations of CoCl₂. The bar graphs show relative protein expression after normalization against β-actin from four independent experiments. CoCl₂ induced a dose-dependent increase in COX-2 expression. ***P < 0.001: 250 μM vs control. (B) Protein expression of COX-2 in HTR-8/SVneo cells treated with different concentrations of 1,25(OH)₂D₃. In contrast to CoCl₂, 1,25(OH)₂D₃ causes a dose-dependent decrease in COX-2 expression in placental trophoblasts. The bar graphs show relative protein expression after normalization to β-actin from three independent experiments. **P < 0.01: treated vs control cells.