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. 2021 May 27;11:11168. doi: 10.1038/s41598-021-90605-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A diagram shows the relationship of vitamin D, VDR, miR-26b-5p and their anti-inflammatory effects on COX-2/PGE₂ signaling in placental trophoblasts. Vitamin D (1,25(OH)₂D₃) binds to its receptor VDR, which can stimulate miR-26b-5p expression. miR-26b-5p subsequently acts on its effector genes to suppress oxidative stress-induced COX-2 expression and PGE₂ release.