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. 2021 May 24;10(5):328–339. doi: 10.1302/2046-3758.105.BJR-2020-0020.R1

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© 2021 Author(s) et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 7 — Mechanism diagram illustrating that microRNA-381 (miR-381) can activate Ras homologous A (RhoA)/Rho-kinase activity to promote the apoptosis of neurones in dorsal root ganglia (DRG) cells by inhibiting bromodomain-containing protein 4 (BRD4). Moreover, miR-381 derived from extracellular vesicles (EVs) in mesenchymal stem cells (MSCs) promoted the recovery of spinal cord injury (SCI) by inhibiting the BRD4/Wnt family member 5A (WNT5A) axis in a rat model.