Table 2.
Major findings of the included studies on diversity.
| Study | Change of alpha diversity in hypertension | Change of beta diversity in hypertension |
|---|---|---|
| Hypertension | ||
| Silveira-Nunes et al. (33) | Shannon index was decreased in hypertension group; phylogenetic diversity and OTUs count were similar in hypertension group and control group | Significant differences between hypertension group and control group were detected |
| Palmu et al. (32) | Alpha diversity was not related to any BP variable in the multivariable-adjusted models | In multivariable-adjusted models, beta diversity was only associated with DBP |
| Calderon-Perez et al. (29) | No significant differences of Shannon index and Chao 1 were seen between different groups | No significant differences were detected |
| Takagi et al. (34) | No significant differences of Shannon index and the observed species were seen between different groups | No significant differences were detected |
| Sun et al. (27) | Hypertension and SBP were inversely associated with measures of alpha-diversity, including Richness (ORs: 0.70~0.79 in different models) and the Shannon Diversity Index (ORs: 0.82~0.90 in different models) | Beta diversity was significantly associated with both hypertension and SBP in all multivariable-adjusted models |
| Mushtaq et al. (26) | Observed species, OTUs, Shannon, Simpson, and Good's coverage were similar in hypertension group and control group; chao1 and ACE were higher in hypertension group than controls group | Significant differences between hypertension group and control group were detected |
| Dan et al. (23) | No significant differences were seen between hypertension group and control group | Significant differences between hypertension group and control group were detected |
| Zuo et al. (28) | Shannon index and Pielou evenness were decreased in hypertension group; Chao richness was similar in hypertension group and control group | - |
| Kim et al. (22) | - | Samples were separate significantly based on bacterial taxonomy |
| Yan et al. (19) | Shannon index was decreased in hypertension group | Overlaps were seen only in part with taxonomic composition based on Bray-Curtis distances |
| Hypertension and borderline hypertension/Pre-hypertension | ||
| Han et al. (20) | No significant differences were seen between different groups | Samples were stratified into two viral-types |
| Li et al. (18) | Shannon index was decreased in hypertension group and pre-hypertension group | Samples were clustered into two enterotypes by PCA of Jensen-Shannon divergence |
| Preeclampsia | ||
| Chang et al. (30) | Shannon index and Sobs index were decreased in hypertension group | Significant differences between hypertension group and control group were detected |
| Pulmonary arterial hypertension | ||
| Kim et al. (31) | Shannon index, Simpson's index and Evenness were decreased in PAH group | Significant differential taxonomic profiles between PAH and control group were observed |
BP, blood pressure; DBP, diastolic blood pressure; OR, odds ratio; OTUs, operational taxonomic units; PAH, pulmonary arterial hypertension; SBP, systolic blood pressure.