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. 2021 May 27;12:3188. doi: 10.1038/s41467-021-23384-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Genomic associations per type for all 33 cancer types in TCGA. Upper panel: enrichment of copy number heterogeneity (CNH) in microsatellite-instable (MSI), genome-doubled or mutated cancers versus non-MSI, non-genome-doubled and non-mutated cancers, respectively. The enrichment of CNH is defined as the log2 of the ratio between group medians with and without event. Lower panel: Spearman’s rank correlation of CNH to aneuploidy and mutational load per cancer type. b Pan-cancer Spearman’s rank correlation between CNH and the aneuploidy score. c Identification of mutated genes related to CNH in a pan-cancer setting. Malignancies are grouped as wild type or mutated for each gene. The relative difference in median CNH of these groups (horizontal axis) and the corresponding significance calculated by the Wilcoxon rank-sum test (vertical axis) are shown. d Spearman’s rank correlation between CNH and mutational load in MSI tumours (green) and non-MSI cancers (grey). e Spearman’s rank correlation between CNH and mutational load per cancer type for all tumours (black), non-MSI tumours (grey) and MSI tumours (green). The relative width of the grey and green bars reflects the ratio of MSI/non-MSI tumours in each type. f Malignancies that have undergone genome doubling have a higher CNH. Groups are compared by the Wilcoxon rank-sum test. Source data are provided as a Source Data file.