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. 2021 May 27;12:3188. doi: 10.1038/s41467-021-23384-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Kaplan–Meier plots of overall survival for uterine corpus endometrial cancer (UCEC), sarcoma (SARC), low-grade glioma (LGG) and acute myeloid leukaemia (LAML). The homogeneous (blue lines) and heterogeneous (red lines) groups were compared by the two-sided log-rank test. b Hazard ratios (HR) of copy number heterogeneity (CNH) for overall survival (OS, left panel) and progression-free interval (PFI, right panel) of all 33 cancer types in TCGA. Hazard ratios were calculated using univariate Cox proportional-hazard models. Red (blue) symbol indicates that the CNH-high (low) group has poorer survival. Significance is indicated by diamonds and marked with an asterisk per type. Error bars represent 95% confidence intervals of hazard ratios as given by the two-sided Wald test. Patients are split in two groups of equal size based on rank-ordered CNH in these survival analyses. Source data are provided as a Source Data file.