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. 2021 May 27;12:3188. doi: 10.1038/s41467-021-23384-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Distribution of copy number heterogeneity (CNH) for 558 microsatellite-instable (MSI) tumours (bars) versus all 10,208 primary cancers (line) in TCGA. Kaplan–Meier plots of progression-free interval (b) and overall survival (c). Patients with MSI tumours are split into three groups of equal size based on rank-ordered CNH in the survival analysis. The most homogeneous (blue) and most heterogeneous (red) groups are compared by the two-sided log-rank test. Source data are provided as a Source Data file.