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. 2021 May 27;11:11210. doi: 10.1038/s41598-021-90700-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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NUMB has an inhibitory role in PCa and PCSCs. (A,B) The TCGA database and StarBase v3.0 (http://starbase.sysu.edu.cn/) were analyzed to detect expression differences of NUMB genes in normal tissues and primary tumors (FPKM = Fragments Per Kilobase Million, TPM = Transcripts Per Million). (C) qRT-PCR was used to detect NUMB expression differences in CD44+ and CD44− PC3 cells. (D) Transwell invasion, clone formation and sphere formation assays were performed with CD44+ PC3 cells transfected with pcDNA3.1-Numb (Over-Numb) or pcDNA3.1-Ctrl (Ctrl-Numb). (E) Transwell invasion, colony formation and sphere formation assays were performed with CD44- PC3 cells transfected with siRNA-Numb (SiNumb) or the control (siRNA-Ctrl).