Table 5.
Relationship between changes (0–7 days) NLR and short-term mortality in patients with ARDS derived from a generalized additive mixed model (GAMM).
| Unadjusted | Adjusted I | Adjusted II | ||||
|---|---|---|---|---|---|---|
| 30-day mortality | β (95%CI) | P-value | β (95%CI) | P-value | β (95%CI) | P-value |
| Day | −0.23 (−0.46, −0.001) | 0.0496 | −0.23 (−0.46, 0.01) | 0.0562 | −0.25 (−0.48, −0.02) | 0.0358 |
| Death | 3.86 (2.43, 5.28) | <0.0001 | 3.43 (1.97, 4.88) | <0.0001 | 2.64 (1.09, 4.19) | 0.0009 |
| Day × death | 0.69 (0.25, 1.13) | 0.0022 | 0.68 (0.24, 1.12) | 0.0026 | 0.67 (0.23, 1.11) | 0.0030 |
| In-hospital mortality | β (95%CI) | P-value | β (95%CI) | P-value | β (95%CI) | P-value |
| Day | −0.30 (−0.54, −0.06) | 0.0132 | −0.29 (−0.53, −0.06) | 0.0159 | −0.31 (−0.55, −0.07) | 0.0103 |
| Death | 3.38 (2.00, 4.77) | <0.0001 | 2.98 (1.56, 4.39) | <0.0001 | 2.22 (0.76, 3.73) | 0.0032 |
| Day × death | 0.75 (0.33, 1.18) | 0.0005 | 0.74 (0.32, 1.16) | 0.0006 | 0.73 (0.31, 1.15) | 0.0007 |
CI, confidence interval; Day, the mean of the increasing of NLR at death = 0 over time (daily); Death, the difference of NLR at day = 0 between the group of death = 1 and the group of death = 0; Day × death, the average increasing in NLR daily under the condition of the group of death = 1 compared with the group of death = 0.
Adjusted I for age, gender, ethnicity, smoking, admission type.
Adjusted II for age, gender, ethnicity, smoking, admission type, COPD, hypertension, tumor, diabetes mellitus, renal failure, SID30, pneumonia, sepsis, aspiration, trauma/surgery, other non-pulmonary, PaO2/FiO2, SAPSII, OASIS, SOFA, corticosteroids therapy, antibiotic therapy, vasopressor therapy, ventilation received, and renal replacement therapy.