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. 2021 May 14;12:654872. doi: 10.3389/fimmu.2021.654872

Figure 1.

Figure 1

Effect of dmLT and LTB on IL-17A responses induced by SEB and PHA stimulation in PBMCs from adults and infants. IL-17A concentrations in cultures with cells from (A) adults (n = 15) and (B) infants (n = 15) stimulated with increasing concentrations of dmLT alone (1 or 10 µg/ml) or with SEB or PHA. (C) Fold changes in IL-17A concentrations in cultures with PBMCs from adults and infants stimulated with SEB or PHA plus dmLT (10 µg/ml) versus SEB or PHA stimulation alone. Bars represent means of fold-change differences and each symbol represents data from one participant. The dashed line indicates no enhancement (fold rise = 1). (D) Effect of LTB (10 µg/ml) on IL-17A responses induced by SEB in PBMCs from adults (n = 7) and infants (n = 7). (A, B, D) Bars represent mean with SEM of IL-17A concentrations in culture supernatants. Statistical analysis was performed using the Friedman test with Dunn’s multiple comparison post-test (A, B), Mann-Whitney test (C) or Wilcoxon matched pairs sign rank test (D) ** P < 0.01, *** P < 0.001, ns, not significant; P > 0.05.