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. 2021 May 14;11:667428. doi: 10.3389/fonc.2021.667428

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Copyright © 2021 Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biogenesis and types of circRNAs. Studies have identified four categories of circRNAs: EcircRNAs, EIciRNAs, ciRNAs and TricRNAs. The four types of circRNAs are formed by different mechanisms. (A) Canonical pre-mRNA splicing to produce a mature mRNA. (B) Intron pairing-driven circularization. (C) RBPs-associated circularization. (D) Lariat-driven circularization. (E) TricRNA is generated during pre-tRNA splicing.