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. 2021 May 14;11:667428. doi: 10.3389/fonc.2021.667428

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Copyright © 2021 Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circRNAs in the EMT regulation in HCC. Activation of Wnt/β-catenin and Notch/NF-KB pathways can induce various EMT-transcription factors. These EMT-transcription factors subsequently lead to repression of epithelial markers (e.g., E-cadherin) expression and increased expression of mesenchymal markers (e.g., N-cadherin and Vimentin), which finally facilitate the EMT. These EMT-associated transcription factors and signaling pathways can be regulated by circRNAs in HCC. circRNAs with pro-EMT effects are denoted as red circles whereas circRNAs with anti-EMT effects are denoted as green circles. Vim, Vimentin; N-cad, N-cadherin; E-cad, E-cadherin.