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Metabolic regulation by circRNAs in HCC. HK2 and PKM2 are important rate-limiting enzymes in the first and last steps of glycolysis, which can be regulated by circRNAs in HCC. circRNAs with pro-glycolysis effects are denoted as red circles. The roles and mechanisms of circRNAs in the regulating of metabolism of lipids and amino acids in HCC have not been discovered. PMK2, pyruvate kinase 2; HK2, hexokinase 2.
