Table 1.
Representative dysregulated circRNAs and potential clinical applications in HCC.
| CircRNAs | Expression | Mechanism | Target genes and signaling pathway | Clinical application | References |
|---|---|---|---|---|---|
| circRHOT1 | ↑ | regulation gene transcription | TIP60-dependent NR2F6 expression | Prognosis | (119) |
| SCD-circRNA 2 | ↑ | regulated by RBM3 | SCD-circRNA2/ERK pathway | Prognosis | (120) |
| circRNA_104348 | ↑ | miRNA sponge | miR-187-3p/RTKN2 | Prognosis | (121) |
| circCAMSAP1 | ↑ | miRNA sponge | miR-1294/GRAMD1A pathway | Prognosis and therapeutic target | (122) |
| circTRIM33–12 | ↓ | miRNA sponge | miR-191/TET1 | Prognosis and therapeutic target | (123) |
| circDLC1 | ↓ | Interaction RBPs | circDLC1-HuR-MMP1 axis | Prognosis and therapeutic target | (124) |
| circ_0091570 | ↓ | miRNA sponge | miR-1307/ISM1 | Diagnosis and prognosis | (125) |
| circ_0014717 | ↓ | miRNA sponge | miR-668-3p/BTG2 | Prognosis | (126) |
| circPABPC1 | ↓ | Protein scaffold | circPABPC1 linked ITGB1 to proteasome for degradation | Prognosis and therapeutic target | (127) |
| exosomal circAKT3 | ↑ | − | − | Prognosis | (128) |
| exosomal circ-0004277 | ↑ | − | − | Diagnosis and therapeutic target | (129) |
| circFBXO11 | ↑ | miRNA sponge | miR-605/FOXO3/ABCB1 axis | Diagnosis, therapeutic target and chemotherapy resistance | (130) |
| circ_0003418 | ↓ | − | Wnt/β-catenin pathway | Diagnosis, therapeutic target and chemotherapy resistance | (131) |
| circRNA_101505 | ↓ | miRNA sponge | miR-103/ONR1 | Therapeutic target and chemotherapy resistance | (132) |
| cZNF292 | ↑ | Bind to proteins | SOX9 nuclear translocation and Wnt/β-catenin pathway | Enhanced radiosensitivity | (133) |
| circRNA-SORE | ↑ | miRNA sponge | Sponging miR-103a-2-5p/miR-660-3p and activating Wnt/β-catenin pathway | Chemotherapy resistance | (134) |
| circRNA-SORE | ↑ | Bind to proteins | Bound and stabilized YBX1 | Chemotherapy resistance | (135) |
| circASAP1 | ↑ | miRNA sponge | miR-326/miR-532-5p-MAPK1/CSF-1 signaling | Prognosis and therapeutic target | (136) |
| circTMEM45A | ↑ | miRNA sponge | miR-665/IGF2 axis | Diagnostic and therapeutic target | (137) |
| Circ-CDYL | ↑ | miRNA sponge | miR-892a-HDGF/PI3K/AKT and miR-3283p/HIF1AN/NOTCH | Early diagnosis and therapeutic target | (138) |
| cSMARCA5 | ↓ | miRNA sponge | miR-17-3p/miR-181b-5p-TIMP3 pathway | Prognosis and therapeutic target | (17) |
| CircMTO1 | ↓ | miRNA sponge | miR-9/p21 pathway | Prognosis and therapeutic target | (16) |