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. 2021 May 14;8:659550. doi: 10.3389/fmolb.2021.659550

FIGURE 5.

FIGURE 5

Structural features of dimeric and tetrameric ALDHs. (A) The C-terminal tail extension of dimeric ALDHs is represented in green against the monomer of ALDH3A1 (Red, PDB: 3SZA). Note the deletion of the first 56 amino acids in comparison to image (B) of the tetrameric ALDH2 (cyan). (B) The “so-called” N-terminal extension is represented in cyan against the monomer of ALDH2 (Blue, PDB: 1NZX). Note the absence of the C-terminal extended tail. (C) LsALDH16 monomer highlighting the NAD binding domain (orange), the catalytic domain (red) and an extra structural domain (green). (D) Surface representation of the dimeric ALDH3A1 (light blue, PDB: 3SZA) superimposed on ALDH2 (Gray, PDB: 1NZX). The C-terminal tail of ALDH3A1 is depicted in red. For clarity, only the opposing dimer of ALDH2 is shown.