FIGURE 6.

Graphical representation of the architecture of ALDHs. (A) ALDH class 1 and 2 being defined by a set of N-terminal residues (yellow) and the lack of the C-terminal tail (green). ALDH class 3 being defined by the absence of N-terminal residues and presence of the C-terminal extension. Note that the TtALDH₅₃₀ contains both this N-terminal segment and the extended C-terminus with LsALDH16 containing a C-terminus constructed by a non-functional Rossmann fold domain. Modified from Hayes, et al. (Hayes et al., 2018). (B) Representation of ALDH functional domains on a typical ALDH and AdhE spirosome of 3 subunits. Note: size of the graphic representation does not directly relate to the size of the domains.