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ALDH hexameric structure (A) Superimposition of the monomers of yeast ALDH4A1 (orange) and TtP5CDH (green) (PDB: 4OE6, 2BHQ, respectively), demonstrating the N-terminal extension equipped with an alpha helix in hexamer forming ALDHs. Extension is shown in red for TtP5CDH and yellow for yeast. (B) The hexameric assembly of TtP5CDH (PDB: 2BHQ) with the N-terminal loop (red) penetrating the pore formed by the hexamer.
