Figure 4.

Effects of [Lys¹²Pal]Ex-4/CCK on glucose tolerance and insulin secretion in C57BL/6 mice. Blood glucose and plasma insulin concentrations were assessed following administration of [Lys¹²Pal]Ex-4/CCK (25 nmol/kg bw, i.p.) in combination (A, B) with glucose (18 mmol/kg bw, i.p.) or (C, D) 4 h, (E, F) 8 h, (G, H) 12 h or (I, J) 24 h prior to glucose administration. 0-60 min glucose AUC values are also shown. Values are mean ± SEM for 8 mice. *p < 0.05, **p < 0.01 and ***p < 0.001 compared with glucose alone control.