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. 2021 May 17;24(1):518. doi: 10.3892/mmr.2021.12157

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Copyright: © Su et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Nrf2 regulates the inhibition of NLRP3 inflammasome activity. Wild-type and Nrf2-KO mice underwent surgery to induce renal I/R via clamping of the bilateral renal pedicles. (A) At 24 h post-reperfusion, renal tissue was collected for western blot analysis of (B) Nrf2, (C) HO-1, (D) NLRP3, (E) ASC, (F) caspase-1 and (G) IL-1β protein expression levels. Data are presented as the mean ± SD (n=3). *P<0.05 vs. Con wild-type mice; ^#P<0.05 vs. I/R wild-type mice. NLRP3, NLR family pyrin domain containing 3; ASC, PYD and CARD domain containing; HO-1, heme oxygenase 1; KO, knockout; Con, control; I/R, ischemia/reperfusion.