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. 2021 May 14;12:672182. doi: 10.3389/fphar.2021.672182

FIGURE 2.

FIGURE 2

Purine nucleotide cycles. 1: 5′-nucleotidase I; 2: adenosine kinase; 3: AMP deaminase; 4: adenylosuccinate synthase; 5: adenylosuccinate lyase; 6: cytosolic 5′-nucleotidase II; 7: adenosine deaminase; 8: IMP dehydrogenase; 9: GMP synthase; 10: purine nucleoside phosphorylase; 11: hypoxanthine guanine phosphoribosyltransferase. The figure also shows that AMP is an activator of AMP-activated protein kinase (AMPK). Ado: adenosine; Gua: guanine; Guo: guanosine; Hyp: hypoxhanthine; Ino: inosine. S-AMP: succinylAMP. +: stimulation.