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. 2021 Apr 20;11(8):e3990. doi: 10.21769/BioProtoc.3990

Figure 1. Schematic representation of the steps to isolate the brain (macro-dissection).

Figure 1.

After decapitation of the newborn mouse, remove the skin to expose the skull (step 1). Cut the skull along the midline using a scalpel (step 2A) and partially remove the skull using a pair of fine tipped tweezers (step 2B). Lift out the intact brain with a scalpel or spatula (step 3A) and place it into a 60 mm Petri dish containing ice-cold dissection medium (DM/Ky.Mg) (step 3B). Schematic representation was created with BioRender.com.