Table 1.
Physiological observations and blood gas results throughout the experiment.
| Normothermia | Hypothermia | |||
|---|---|---|---|---|
| Mean | (SD) | Mean | (SD) | |
| Weight (g) | 2008 | (132) | 2075 | (161) |
| Rectal temp ( °C) | ||||
| Baseline | 37.9 | (0.8) | 37.6 | (0.4) |
| 4 h LPS | 38.6 | (0.3) | 38.6 | (0.3) |
| End of insult | 38.1 | (0.5) | 38.1 | (0.3) |
| 1–25 h | 38.4 | (0.1) | 34.0 | (0.5)** |
| 25–35 h | 38.7 | (0.1) | 36.5 | (1.3)** |
| 35–48 h | 38.4 | (0.2) | 38.2 | (0.2) |
| Heart rate (b.p.m.) | ||||
| Baseline | 169.1 | (26.0) | 151.7 | (11.9) |
| 4 h LPS | 192.9 | (15.0) | 185.0 | (12.6) |
| End of insult | 237.3 | (15.8) | 225.6 | (12.9) |
| 1–25 h | 234.9 | (20.5) | 170.9 | (24.8)** |
| 25–35 h | 210.0 | (25.2) | 180.0 | (8.7)* |
| 35–48 h | 185.2 | (21.7) | 173.0 | (13.1) |
| MABP (mm Hg) | ||||
| Baseline | 51.1 | (4.3) | 52.1 | (1.4) |
| 4 h LPS | 53.1 | (3.7) | 54.1 | (5.8) |
| End of insult | 47.3 | (6.3) | 43.7 | (5.6) |
| 1–25 h | 45.7 | (5.4) | 42.7 | (9.8) |
| 25–35 h | 55.0 | (5.2) | 42.8 | (15.0) |
| 35–48 h | 49.5 | (2.9) | 54.8 | (4.5) |
| pH | ||||
| Baseline | 7.48 | (0.19) | 7.57 | (0.10) |
| 4 h LPS | 7.44 | (0.10) | 7.45 | (0.07) |
| End of insult | 7.22 | (0.11) | 7.25 | (0.13) |
| 12 h | 7.49 | (0.07) | 7.44 | (0.17) |
| 24 h | 7.47 | (0.03) | 7.38 | (0.13) |
| 48 h | 7.47 | (0.04) | 7.48 | (0.05) |
| PaCO2 (kPa) | ||||
| Baseline | 6.3 | (3.4) | 4.3 | (0.8) |
| 4 h LPS | 5.8 | (1.0) | 5.6 | (0.7) |
| End of insult | 6.3 | (1.8) | 5.6 | (0.9) |
| 12 h | 5.3 | (0.6) | 4.4 | (1.1) |
| 24 h | 5.4 | (0.7) | 5.1 | (1.3) |
| 48 h | 5.2 | (0.6) | 5.0 | (0.4) |
| PaO2 (kPa) | ||||
| Baseline | 18.6 | (2.7) | 15.0 | (4.3) |
| 4 h LPS | 10.4 | (1.1) | 10.8 | (0.9) |
| End of insult | 3.6 | (0.4) | 3.7 | (0.9) |
| 12 h | 13.7 | (4.8) | 15.5 | (6.6) |
| 24 h | 12.8 | (3.1) | 10.7 | (4.0) |
| 48 h | 15.2 | (3.9) | 14.6 | (1.8) |
| BE (mmol/L) | ||||
| Baseline | 8.5 | (3.3) | 7.7 | (4.4) |
| 4 h LPS | 5.9 | (3.4) | 5.1 | (3.4) |
| End of insult | −9.0 | (2.9) | −8.7 | (4.9) |
| 12 h | 6.8 | (3.4) | −0.3 | (10.5) |
| 24 h | 5.7 | (2.1) | −1.7 | (9.8) |
| 48 h | 4.5 | (2.4) | 5.4 | (4.9) |
| Lactate (mmol/L) | ||||
| Baseline | 3.6 | (1.7) | 2.9 | (1.2) |
| 4 h LPS | 4.1 | (2.0) | 3.4 | (1.3) |
| End of insult | 13.1 | (1.7) | 11.0 | (2.2) |
| 12 h | 3.0 | (0.6) | 6.6 | (5.0) |
| 24 h | 2.3 | (0.8) | 6.7 | (7.1) |
| 48 h | 1.1 | (0.2) | 1.3 | (0.3) |
| Glucose (mmol/L) | ||||
| Baseline | 4.9 | (1.3) | 5.2 | (1.2) |
| 4 h LPS | 6.0 | (2.2) | 5.6 | (0.5) |
| End of insult | 8.9 | (3.0) | 7.9 | (1.0) |
| 12 h | 6.8 | (1.2) | 11.5 | (5.6) |
| 24 h | 6.5 | (1.2) | 10.3 | (3.6)* |
| 48 h | 4.5 | (1.2) | 4.9 | (0.7) |
| Potassium (mmol/L) | ||||
| Baseline | 4.1 | (0.7) | 4.5 | (0.4) |
| 4 h LPS | 4.5 | (0.4) | 5.0 | (0.4) |
| End of insult | 4.5 | (0.5) | 5.2 | (0.8) |
| 12 h | 6.3 | (0.7) | 6.3 | (1.0) |
| 24 h | 6.7 | (0.7) | 6.7 | (1.4) |
| 48 h | 5.7 | (1.2) | 6.2 | (1.3) |
MABP mean arterial blood pressure, BE base excess.
*P < 0.05, **P < 0.005.