Table 2.
CYP | Known Phenotypes | Substrates | Phenoconversion |
---|---|---|---|
1A2 | increased funtion normal function unknown function |
duloxetine, olanzapin, clozapine, theophyllin, caffeine | fluvoxamine, ciprofloxacine, enoxacine, smoking |
2A6 | PM, IM, NM, UM | nicotine | |
2B6 | NM, IM, PM, RM, UM | bupropion, cyclophospamide, efavirenz, methadone | clopidogrel, ticlopidine, tenofovir, voriconazole, carbamazepine, efavirenz, rifampin |
2C8 | increased function normal function decreased function |
glitazones, paclitaxel | gemfibrozil, clopidogrel, teriflunomide, trimethoprim, rifampin, St. John‘s wort |
2C9 | NM, IM, PM | losartan, NSAIDs, phenytoin, warfarin, glyburide | amiodarone, fluconazole, miconazole, rifampin |
2C19 | NM, IM, PM, RM, UM | clopidogrel, diazepam, proton pump inhibitors (PPI) | fluvoxamine, fluoxetine, fluconazole, omeprazole, ticlopidine, rifampin |
2D6 | NM, IM, PM, UM | antidepressants, betablockers, codeine, tramadol, tamoxifen, hydrocodone | bupropion, cimetidine, duloxetine, fluvoxamine, fluoxetine, paroxetine, quinidine, Note: there are no known inducers of CYP2D6. |
3A4 | normal function, decreased function, increased function | calcium channel blockers, macrolides, protease inhibitors, statins | azole antimycotics, boceprevir, cobicistat, danoprevir, grapefruit, ritonavir, telaprevir, verapamil, carbamazepine, phenobarbital, phenytoin, rifampin, St. John’s wort |
3A5 | NM, IM, PM Note: activity has major influence on CYP3A4 activity, if *1 is present |
Tacrolimus, quetiapine | Ciprofloxacin, erythromycin, diltiazem, ketoconazole, verapamil |