Table 4.
Enzyme | Known Phenotypes | Substrates | Phenoconversion |
---|---|---|---|
UGT1A1 | NM, IM, PM | bilirubin, irinotecan, estradiol | Atazanavir, carbamazepine, phenytoin, phenobarbital, rifampicin, ritonavir, lamotrigin, efavirenz, tyrosine-kinase inhibitors |
UGT1A4 | Normal function, increased function, decreased function | valproic acid, lamotrigine, allopurinol, febuxostat, tamoxifen, clozapine, anastrozole | methylene blue, ertugliflozin, carbamazepine, phenytoin |
UGT1A6 | n.a. | allopurinol, febuxostat, methothrexat, valproic acid | troglitazone, fosphenytoin, phenytoin, carbamazepine |
UGT1A9 | n.a. | allopurinol, febuxostat, methothrexat, valproic acid | vandetanib |
UGT2B7 | n.a. | zodovudine, oxycodone, efavirenz, methadone, lamotrigine, morphine, codeine, fentanyl. | flunitrazepam, ketoconazole, umifenovir, phenobarbital, mefenamic acid |
UGT2B15 | normal function decreased funtion |
oxazepam, lorazepam | |
N-acetyltransferase (NAT2) | fast slow |
isoniazid, hydralazine, dapsone, caffein, procainamide | |
Thiopurine Methyl Transferase (TPMT) | NM, IM, possibly intermediate, PM | thiopurines | allopurinol |
Nudix hydrolase 15 (NUDT 15) | NM, IM, possibly intermediate, PM | thiopurines |