Table 5.
Gene/Transporter | Known Phenotypes | Substrates | Phenoconversion |
---|---|---|---|
OATP1B1/SLCO1B1 gene | normal function, decreased function, poor function | atorvastatin, repaglinide, enalapril, methotrexate, rosuvastatin, simvastatin, eryhtromycin, nateglinide, pitavastatin, pravastatin, lopinavir | astemizole, diazepam, nifedipine |
BCRP/ABCG2 gene | Normal function, decreased function | allopurinol, asuvastatin, leflunomide, sunitinib, topotecan, pitavastatin, rosuvastatin, sulfasalazine | curcumine, elacridar, cyclosporine A |
P-glycoprotein/ABCB1/MDR1 gene | normal function, increased function |
colchicine, fexofenadine, simvastatin, rifampin, cyclosporine, ondansetron, risperidone, digoxin, fentanyl, methadone, oxycodone, tramadole, phenytoin | amiodarone, carvedilol, clarithromycin, quinidine, verapamil, ritonavir, telaprevir, carbamazepine, St. John’s wort, primidone, rifampin, phenytoin |