Table 2.

Analysis of risk of bias studies for five (5) NRSIs and one (1) RCT.

Study Author & Year	ROBIN-I (Risk of Bias in Non-Randomised Studies of Interventions)		RoB-2 (Risk of Bias in Randomised Studies of Interventions [RCT])
	Risk-of-Bias Judgement	Overall Predicted Direction of Bias	Risk-of-Bias Judgement	Overall Predicted Direction of Bias
Bainbridge et al., 2015	Low/Moderate	Towards null/Unpredictable	N/A	N/A
Jacobson et al., 2012	Low/Moderate	Towards null/Unpredictable	N/A	N/A
Le Meur et al., 2018	Low/Moderate	Towards null/Unpredictable	N/A	N/A
Russell et al., 2017	N/A	N/A	Some concerns	Favours experimental
Testa et al., 2013	Low/Moderate	Towards null/Unpredictable	N/A	N/A
Weleber et al., 2016	Low/Moderate	Towards null/Unpredictable	N/A	N/A