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ALT and bilirubin abnormalities noted in maraviroc phase 1 multiple-dose studies.
| Phase 1 Multiple-Dose Studies [100] | ||
|---|---|---|
| ALT | Maraviroc (n = 272) | Placebo (n = 42) |
| >2 to ≤ 5× ULN | 8 (2.9%) | 0 |
| >5× ULN | 1 (0.4%) | 0 |
| Bilirubin—Total | (n = 272) | (n = 41) |
| >1.25 to ≤ 2.5× ULN | 3 (1.1%) | 0 |
| >2.5× ULN | 0 | 0 |
Abbreviations: ALT, alanine transaminase; AST, aspartate aminotransferase; ULN, upper limit of normal.
