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. 2021 May 20;22(10):5374. doi: 10.3390/ijms22105374

Figure 2.

Figure 2

ATX induces DDR2 expression. (a) ES2 cells were transfected with the indicated vectors and then the resulting cell lysates were subjected to immunoblot analysis (mean ± s.d. ** p < 0.01 versus control). (b) ES2 cells were transfected with the indicated vectors and then treated with HA-130 (5 μM) for 24 h before being subjected to immunoblot analysis (mean ± s.d. *** p < 0.001 versus control and ### p < 0.001 versus ATX overexpression). (c) ES2 cells were co-transfected with the indicated vectors and siRNAs prior to invasion assay (mean ± s.d. * p < 0.05 and *** p < 0.001 versus control, # p < 0.05 and ### p < 0.001 versus ATX overexpression). (d) Correlation between DDR2 and ENPP2 gene expression in ovarian cancer. Empty vectors and scrambled siRNA were used as controls. Representative results were presented from at least three independent experiments with similar results.