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Morphological changes accompanied tamoxifen resistance development; (A) untreated control MCF-7 cells, (B) MCF-7 cells treated with 30 µM tamoxifen and (C) MCF-7 cells treated with 40 µM tamoxifen. Arrows indicate the change in cell shape in comparison to the epithelial-like shape of MCF-7 cells. Images were taken using ZOE Fluorescent Cell Imager (Bio-Rad, Hercules, CA USA) (scale bar 100 μm). Experiments were repeated at 3 different times.
