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. 2021 May 19;10(5):626. doi: 10.3390/pathogens10050626

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Total IgG, IgG1, and IgG2a endpoint titers to SARS-CoV-2 antigens from day 71 mice sera. (A) Total IgG endpoint titers to the spike (S), the receptor-binding domain (RBD), and the nucleocapsid (N) SARS-CoV-2 antigens. (B) IgG1 and IgG2a endpoint titers to RBD. Each symbol represents one mouse, and horizontal lines represent group median values. Student’s t-tests were used to compare differences between groups. * indicates significant differences between adjuvant and PsIV group vs corresponding adjuvant alone group, as well as between DNA vaccine group vs corresponding DNA/PsIV prime-boost group.

Total IgG, IgG1, and IgG2a endpoint titers to SARS-CoV-2 antigens from day 71 mice sera. (A) Total IgG endpoint titers to the spike (S), the receptor-binding domain (RBD), and the nucleocapsid (N) SARS-CoV-2 antigens. (B) IgG1 and IgG2a endpoint titers to RBD. Each symbol represents one mouse, and horizontal lines represent group median values. Student’s t-tests were used to compare differences between groups. * indicates significant differences between adjuvant and PsIV group vs corresponding adjuvant alone group, as well as between DNA vaccine group vs corresponding DNA/PsIV prime-boost group.