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. 2021 May 20;9(5):581. doi: 10.3390/biomedicines9050581

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of AMA on the GR/PLC/PKC signaling pathway in PC12 cells. (a–c) Effect of GR (RU486), PLC (U73343) and PKC (Go6983) inhibitors on the neurite outgrowth induced by AMA and AMA combined with the NGF. (d) AMA-stimulated phosphorylation of GR, PLC and PKC proteins in a time-dependent manner and the quantification of Western blots by using ImageJ software. (e) Phosphorylation of GR, PLC and PKC induced by AMA or AMA combined with the NGF reduced by the corresponding inhibitors and quantified using Western blots through ImageJ software. Each experiment was repeated three times. *** indicates significant differences at p < 0.001 compared with the negative control; ^### indicates a significant difference at p < 0.001 compared with the 3 μM AMA group and ^$$$ indicates a significant difference at p < 0.001 compared with the AMA-combined NGF group.