Table 1.
E2- and E4-gene signatures.
| E2 | E4 | |||||
|---|---|---|---|---|---|---|
| Gene | Log2 Fc | Adj p-value | Gene | Log2 Fc | Adj p-value | |
| Upregulation | LINC01426 | 2.60402 | 0.00148 | ALX4 | 3.42629 | 0.00009 |
| PCDHB7 | 2.31027 | 0.00546 | IGF2 | 2.46035 | 0.00923 | |
| CTB-178M22.2 | 2.08914 | 0.00193 | DCLK2 | 1.91340 | 0.00299 | |
| OTOF | 2,33653 | 0.00589 | AARD | 1.89141 | 0.00188 | |
| KLRG1 | 1.86945 | 0.00994 | EREG | 1.87651 | 0.00002 | |
| MIR3153 | 1.81026 | 0.00603 | F5 | 1.81722 | 0.00770 | |
| KCNRG | 1.72432 | 0.00064 | CCDC73 | 1.81317 | 0.00605 | |
| CFAP58-AS1 | 1.67121 | 0.00079 | HOXB2 | 1.77432 | 0.00005 | |
| C4orf47 | 1.60288 | 0.00488 | NAALADL2-AS2 | 1.72651 | 0.00017 | |
| CDKL1 | 1.56006 | 0.00018 | TEX15 | 1.66229 | 0.00932 | |
| Downregulation | LMO3 | −2.80268 | 0.00128 | ODAM | −2.59037 | 0.00098 |
| ABCC6P1 | −2.80138 | 0.00244 | ABHD11-AS1 | −2.53907 | 0.00021 | |
| GUCY1B3 | −2.80121 | 0.00211 | MAGEC1 | −2.36747 | 0.00118 | |
| TSPEAR-AS1 | −2.63897 | 0.00351 | LRRC39 | −2.35825 | 0.00007 | |
| CEMP1 | −2.63778 | 0.00374 | NCALD | −2.25073 | 0.00003 | |
| LOC101929584 | −2.48102 | 0.00399 | CD4 | −2.23406 | 0.00861 | |
| CFAP57 | −2.02884 | 0.00452 | CECR1 | −2.01936 | 0.00307 | |
| MIR24-1 | −1.98172 | 0.00827 | PAX7 | −1.95793 | 0.00975 | |
| LOC102724450 | −1.97767 | 0.00351 | HAPLN1 | −1.95591 | 0.00021 | |
| PLA2G10 | −1.93472 | 0.00159 | RPLP0P2 | −1.84793 | 0.00017 | |
Genes up- or down-regulated by E2 (10−9M) or E4 (10−7M) in comparison with vehicle condition obtained by RNAseq analysis, adjusted p-value: adj p-value, Fc: Fold change; n = 5 replicates per condition.