| IgE | IgG4 to IgE Ratio | |
|---|---|---|
| I. Peanut anaphylaxis: rapid allergic reactions occurring with peanuts or other foods. High titer IgE to defined proteins from the relevant foods. Increase: decrease in the skin barrier possibly related to detergents; a strong correlation with atopic dermatitis. |
High | ~1:1 |
| II. Eosinophilic esophagitis (EoE): delayed onset of symptoms (i.e., days); low IgE and high or very high IgG4 to cow’s milk and/or wheat proteins. Increase: food processing and damage to the esophageal barrier. |
Low or negative | ~500:1 |
| III. Delayed anaphylaxis to mammalian meat: alpha-gal syndrome (AGS) reactions delayed in onset but can be severe. Increase: increased bites from Lone Star ticks; in the USA, associated with an extraordinary increase in the deer population close to houses. |
Low to high | ~1:1 |
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