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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Mechanisms of action of metformin and cellular outcomes. Proteins affected by metformin, either via AMPK-dependent and AMPK-independent pathways, are indicated. In red are outcomes that are inhibited by metformin. In blue are those that are enhanced by metformin.