Pain Paracetamol NSAID (for short periods, e.g., up to 7 days) Gabapentin or pregabalin Tricyclics, such as amitriptyline Low dose naltrexone Duloxetine Venlafaxine Sleep Tricyclics, e.g., amitriptyline Trazodone Melatonin Doxepin low dose Diphenhydramine Promethazine Benzodiazepines and Z-drugs (for short periods only) Gabapentin/pregabalin Autonomic dysfunction, e.g., POTS Fludrocortisone SSRI Midodrine Ivabradine Pyridostigmine Anti-allergic/anti-inflammatory Antihistamines, e.g., fexofenadine or famotidine Sodium cromoglicate Supplements which may be tried for symptoms such as fatigue or cognitive dysfunction Iron (if ferritin < 50 ug/l, transferrin saturation <20%) Vitamin D L-carnitine or acetyl-carnitine CoQ-10 or MitoQ NADH Vitamin B12. α-lipoic acid Magnesium Omega-3 or omega-3/omega-6 combination D-Ribose Vitamin B1, B2, and/or B6 Vitamin C

* Refer to local guidelines on the use of medications that are not specifically licensed for use in ME/CFS.