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. 2021 May 19;13(10):2485. doi: 10.3390/cancers13102485

Figure 2.

Figure 2

MiRNAs regulated by envelope and non-structural proteins in host cells. E2 proteins induce the release of exosomal miR-490 from mast cells and its internalization by hepatocytes reduced cell migration. NS3 proteins, by modulating miR-155, miR-21, and miR-122, determine inflammation, immune escape, and fibrosis. NS4B, through the modulation of miR-27a and b, affects the lipid metabolism. NS5A inhibits the expression of two oncosuppressor miRNAs, miR-503 and miR-181c.