Figure 1.

FGF23 signaling and cardiac hypertrophy. Abbreviations: FGF23-fibroblast growth factor 23, FGFR4—fibroblast growth factor receptor 4, PLCy—phospholipase C y, Ca²⁺—calcium, NFAT—nuclear factor of activated T-cells, β-MHC—β-myosin heavy chain (β-MHC), ANP—atrial natriuretic peptide, BNP—brain natriuretic peptide, Rcan1—regulator of calcineurin 1, LRP 5/6—lipoprotein-receptor-related proteins 5 and 6, DLV—Disheveled protein, APC—Adenomatous Polyposis Coli, GSK3β—glycogen synthase kinase 3β, YAP—Yes-associated protein, TAZ—transcriptional coactivator with PDZ-binding domain, β-Trcp—beta-transducin repeat containing E3 ubiquitin protein ligase, LEF/TCF—lymphoid enhancer-binding factor/β-catenin-T-cell factor, ATII—angiotensin II, AT1R—angiotensin II receptor type 1, NCX—sodium-calcium exchanger, ER—endoplasmic reticulum, RyR—ryanodine receptor, SERCA—sarcoendoplasmic reticulum Ca²⁺ ATP-ase, CaMKII—Ca²⁺/calmodulin kinase II.