Table 1.
Cell-Type Specific Expression of Major Efferocytic Receptors.
| Cell Type | Receptors | Citations |
|---|---|---|
| Tissue-Resident Macrophages 1 | MERTK 2, Axl 2, TIM-4, Stabilin 1, Stabilin 2 2, αvβ5, αxβ2, CD36, SCARF-1, LRP-1 | [66,67,68,69,70,71,72,73,74,75,76] |
| Bone Marrow Derived Macrophages | MERTK 2, Axl 2, TIM-4, Stabilin 1, Stabilin 2, αvβ5, αvβ3, αxβ2, CD36, SCARF-1, LRP-1 | [66,67,77,78,79,80,81,82,83] |
| Dendritic cells | Tyro3, Axl, MERTK 2, TIM-4 2, Stabilin 1, αvβ5, SCARF-1 | [80,84,85,86,87] |
| Microglia | Axl, MERTK, TIM-4, Stabilin 1, αvβ5, αvβ3, BAI-1 | [66,79,88,89,90,91,92] |
| Kidney Tubule Epithelial Cells | TIM-1 | [93] |
| Retinal Pigment Epithelium Cells | MERTK, αvβ5 | [94,95] |
| Myoblasts 3 | BAI-1 | [96] |
| Osteoclasts | BAI-1, TIM-4, Stabilin 1 | [97] |
1 Tissue-resident macrophages are the predominant efferocyte in most tissues. 2 Relative expression of these receptors can change based on extracellular stimuli. 3 BAI-1 expression in myoblasts mediates cell fusion; efferocytic myoblasts have not been reported.