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. 2021 May 20;13(5):947. doi: 10.3390/v13050947

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histopathology and immunohistochemistry (IHC) against rabie nucleoprotein (N) on cSN-KBLV-infected and uninfected mouse brains. (A,B) A cSN-KBLV ic challenged mouse brain. Areas of neuronal necrosis with pyknotic nuclei and karyorrhectic cellular debris (outlined with black dashed-line box) observed in the thalamic region adjacent to the third ventricle (left, H&E stain) and serial-stained sections for N protein revealed abundant intralesional virus antigens (right, IHC, white dashed line box for region of interest co-localised with H&E section). (C,D) A cSN-KBLV IC-challenged mouse brain. Areas of neuronal necrosis characterised by red, angular and shrunken neurons (outlined with dashed-line box) in the hippocampus (left, H&E) where IHC-stained serial tissue section revealed abundant intralesional virus antigens (right, IHC). (E,F) Negative control. Representative sections showing no histological changes or virus antigens in the hippocampus. Images taken at 200x magnification. Insets show digitally magnified region of interest.