Table 1.

Purinergic mediated responses and role in AD of P1 and P2 receptors expressed in neuronal, astrocytic, and microglial cells.

Purinergic Receptor	Cell Type	Response	Role in AD	Refrerences
A1	Neuron	TAU translocation	positive	[36]
		Non-Am. APP Processing	Positive	[36]
A2A	Neuron	Aβ-Induced Neurotoxiciy	Negative	[54,59,60,66,68,69]
	Neuron	Increased Aβ accumulation	Negative	[84,85]
	Neuron	Tau pathology	Negative	[71,72]
	Neuron	Memory damage	Negative	[84]
	Astrocytes	Memory function	Negative	[62]
	Microglia	Neuroinflammation	Negative	[75,76]
A2B	Neuron	Mitochondrial function	Positive	[39,40]
A3	Microglia	Decrease of inflammation	Positive	[44]
P2X4	Neuron	Neurotoxicity	Negative	[86,87]
P2X7	Microglia	Inflammation	Negative	[88,89,90,91,92,93,94]
	Neuron	Amyloidogenic	Negative	[95,96,97]
P2Y1	Astrocyte	Hyper-Activation	Negative	[98]
	Neuron	Synaptic damage	Negative	[98]
P2Y2	Neuron	Neurite Development	Positive	[95]
	Neuron	Non-Am. APP Processing	Positive	[99]
P2Y4	Microglia	Uptake Aβ1-42	Positive	[100]
P2Y6	Microglia	Phagocytosis	Positive	[86]
P2Y12	Microglia	Migration	Positive	[101]
P2Y13	Neuron	Decrease ROS-induced death	Positive	[102]