Figure 6.

Panel (A) shows the evolution of the weights of all 6 components from the RED analysis of the Ketanserin (KET)-bound 5-HT_2AR. Panel (B) shows the weight profile of component 2. The colored vertical lines denote the trajectory frames corresponding to the snapshots of the GPCR/KET complex shown in panels (C–G), which represent the structure before, during and after the event, dominated by component 2. The 5-HT_2AR-Ketanserin complex is show in cyan, with the ICL1 colored in blue, the ICL2 colored in brown, and N4.37 and N2.37 shown in stick model. Panel (H) shows a superposition of the crystal structure of the 5-HT_2AR bound to the inverse agonist risperidone (pdb 6A93, in red) with the structure of the 5-HT_2AR-Ketanserin complex (colored gold) at the time corresponding to frame G (gold line in panel (B).