. 2021 May 20;10(5):1269. doi: 10.3390/cells10051269

Table 2.

Molecules involved in T cell migration through afferent LVs to dLNs.

Molecule	Comments	References
CCR7/CCL21	In mice, Ccr7^−/− T cells display a profound reduction in migration from peripheral tissues to dLNs. In humans, all recirculating memory T cell subtypes are CCR7⁺	[41] [147]
S1P	Treatment with FTY720 reduced T cell migration to LNs Blocking of S1P1 and S1P4 reduce entry of T_eff CD4+ into afferent LVs S1P2 in LECs regulates T cell motility and transmigration	[82] [162] [162]
CD44/Macrophage mannose receptor (MMR)	Interaction of MMR in LECs with CD44 in T cells mediates CD4⁺ and CD8⁺ egress from skin	[169,170]
CLEVER-1	CLEVER-1 blockade reduces CD4⁺ and CD8⁺ T cell migration from the skin to the dLN	[171,172]
ICAM-1/VCAM-1	T cells require LFA-1/ICAM-1 interactions promoting T cell crawling and overall migration through afferent LVs T_reg migration to dLNs depends on VCAM-1 T_H1 cell migration to dLNs depends on VCAM-1	[65] [65,152]
Lymphotoxin (LT)	Blockade of LTBR that binds to VCAM-1 reduced T_reg exit from the skin T_reg modulate LECs for transmigration of other cells, by stimulating LEC LTBR, to increase VCAM-1 and CCL21	[48]
CD69	CD69 downregulates S1P1, thereby inhibiting T cell egress from skin Cd69^-/- T cells can enter the skin but do not form a T_RM population	[166] [165]
MECA-32 (PLVAP)	PLVAP expressed by LN LECs mediates lymphocyte entry across the subcapsular sinus into the LN parenchyma	[30]