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Retinal and RPE morphologies in rd9 mice aged 12 (A,B) and 20 months (C,D). (A,C) Retinal vertical sections. DAPI nuclear staining. Note the progressive thinning of the ONL from (A–C) and the poor retinal layering compared with the wt of Figure 1A. (B,D) ZO-1 staining of RPEs. Arrows point to large discontinuities, evident at 20 months (D). All images are from the central retina/RPE.
