. 2021 May 17;143(20):7777–7791. doi: 10.1021/jacs.1c01925

Table 2. Apparent pK_a^ave Values of the Acidic Residues of α-Synuclein Calculated for Both the Monomers and Fibrils^a.

	pK_a monomers	pK_a fibrils	ΔpK_a^ave
Wild-type	4.3	5.4	1.1
5Q mutant	4.2	4.7	0.5

Based on this, the upshift in the apparent pK_a^ave values, ΔpK_a^ave, was calculated.

Table 2. Apparent pKaave Values of the Acidic Residues of α-Synuclein Calculated for Both the Monomers and Fibrilsa.