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. 2021 May 12;121(10):5633–5670. doi: 10.1021/acs.chemrev.0c00901

Figure 15.

Figure 15

Collision-induced dissociation process (CID-MS/MS) in a collision cell. Ions formed by, e.g., electrospray ionization enter the mass spectrometer and pass a neutral curtain gas (He, Ne, Ar). Once energy is transferred from the collision, molecules can dissociate or rearrange. Ions are further accelerated toward the detectors and registered as specific m/z signals. The collision gas and neutral reaction products are removed by the vacuum pumps of the instrument.