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. 2020 Jan 16;51(6):1038–1048. doi: 10.1017/S0033291719004033

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© The Author(s) 2020

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Effects of stress on SN functional connectivity in siblings of schizophrenia patients and controls. (a) Group (control/sibling) × stress (stress/no-stress) interaction in SN connectivity during acute stress. Controls and siblings differed in SN connectivity directly after stress (group × stress interaction (p_svc < 0.05)) in the right insula. Follow up comparisons revealed that this was driven by a stress-induced increase in healthy controls but not in siblings. (b) Reduced SN connectivity in the aftermath of stress (blue) and a group (control/sibling) × stress (stress/no-stress) interaction (green) in the aftermath of stress. Functional connectivity between the SN and the right anterior insula decreased in the aftermath of stress in both healthy controls and siblings of schizophrenia patients (blue, no-stress > stress p_svc = 0.048). Additionally, there was a decrease in functional connectivity between the SN and the posterior insula in the aftermath of stress in siblings (green, group × stress interaction p_svc = 0.032 and p_svc = 0.057). T-Maps are thresholded at p < 0.001 uncorrected and overlaid onto a normalized anatomical scan for visualization purposes. For a color version, see this figure online. See Table 2 for cluster level inferences.